Cisplatin induced ros
WebPurpose: This study aimed to quantify synergetic effects induced by bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based … WebDec 16, 2024 · Moreover, previous studies have demonstrated that cisplatin accumulates in mitochondria and causes significant changes in mitochondrial structure and metabolic function [ 11, 12 ]. Recent reports evinced that cisplatin-induced apoptosis could be inhibited by compounds that interfere with ROS generation.
Cisplatin induced ros
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WebAug 6, 2015 · Cisplatin induced mitochondrial dysfunction through mitochondrial reactive oxygen species (mROS) that also interfered with the tricarboxylic acid (TCA) … WebSep 14, 2024 · Cisplatin is one of the largest classes of valuable clinical chemotherapeutic agents against various malnancies. 1, 2 However, the ototoxicity induced by cisplatin is one of the most serious adverse effects of cisplatin administration, which results in irreversible, progressive, bilateral and accumulative hearing impairment, thereby limiting …
WebNational Center for Biotechnology Information WebFeb 15, 2024 · Cisplatin or doxorubicin induces pyroptosis of renal tubular epithelial cells It has been reported that the typical characteristics of pyroptosis were increased LDH release, increased PI-positive...
WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebSep 18, 2024 · NCBI Bookshelf
WebNov 7, 2024 · Cisplatin is a well-known inducer of ROS 17, 18, 19 but the intracellular origin of ROS production is not fully understood. An important source of ROS in mammalian …
WebWe found that cisplatin treatment led to SGN damage, in which reactive oxygen species (ROS) generation increased, PINK1 expression decreased, BAD accumulation on mitochondria raised and mitochondrial apoptotic pathway activated. Conversely, we demonstrated that PF pre-treatment obviously mitigated cisplatin-induced SGN damage. phoenix nights online freeWebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … phoenix nights live dvdWebAug 1, 2024 · The cisplatin group showed an approximately 1.6-fold greater fluorescent intensity than the control group, indicating a cisplatin-induced increase in ROS levels. By contrast, the ALA... how do you find old death noticesWebDec 21, 2024 · Cisplatin is a potent first-line of chemotherapeutic drug for treating various neoplasms, but its administration in hospital settings is hampered due to its untoward nephrotoxicity. Previous investigations indicated that about 30% of cisplatin-treated patients (at the dose of 50–100 mg/m 2) developed AKI [ 7 ]. how do you find old obituaries for freeWebJan 15, 2024 · Cisplatin is a chemotherapeutic agent widely used to treat various malignancies, and its application is greatly limited due to its nephrotoxicity, including its onset of acute kidney injury (AKI) [ 1 ]. Undoubtedly, effective drugs to prevent cisplatin-induced AKI (Cis-AKI) in clinical practice are in urgent demand. how do you find office space to rentWebJan 22, 2016 · Cisplatin-based therapy is one of the most important chemotherapy treatments for cancers. However, its efficacy is greatly limited by drug resistance and undesirable side effects. Therefore, it is of great importance to develop effective chemosensitization agents to cisplatin. phoenix nights physic nightWebJun 10, 2024 · Background: Excessive accumulation of reactive oxygen species (ROS) has been documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However, numerous antioxidants have failed in clinical studies partly due to inefficient drug delivery to the cochlea. A drug delivery system is an attractive strategy to overcome this … how do you find old medical records